Mitosis In Cancerous Cells

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as cancer. During which, cancer cells do not respond normally to the body's control mechanisms. They often divide excessively, invade other tissues and, if unchecked, can kill the whole organism. Researchers studying cancer cells in culture have found that they do not respond to the normal signals that stop growth such as contact inhibition. They continue to grow until nutrients in the growth medium are exhausted. Other differences exist between normal and cancer cells. These indicate abnormalities in the cell cycle of cancer cells. Cancer cells that stop dividing do so at random points in the cycle, instead of the restriction point in G1 also known as Gap 1 in the cell cycle.
Cancer cells in culture continue to divide indefinitely as long as nutrients are available. Normal cells in culture divide only about 20 to 50 times before they stop. It is clear that genetic changes are responsible for these abnormalities. However, the exact reasons the cells stop in the middle of the cell ...

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at the level of the genome.
Chemical carcinogens function to convert normal cells to cancerous cells by inducing mutations in genes that are critical for regulation of cell replication. A simple screening test for chemicals to check whether they are likely to be carcinogenic to many life forms is the Ames test, developed at Ames University in Iowa, USA. The test involves the exposure of special strains of a bacterium to the suspected carcinogen. If the suspected carcinogen induces nutritional mutations in the bacteria, it is deemed wise not to allow higher life forms to be exposed to the suspected carcinogen.
The use of bacterial (prokaryotic) cells for testing suspected carcinogens ...

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