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The Conserved Function Of Skp1 - Online Term Paper

The Conserved Function Of Skp1

Skp1 Reserving In Meiosis

Many components of regulatory networks governing basic cellular functions are highly homologous in diverse species. An important question is how such conservation of individual components is translated into the conservation at the level of regulatory networks. An intriguing case regarding this question is concerned with the function of the Skp1 protein in meiosis. Skp1 is a conserved subunit of the Skp1-Cullin-F-box-protein (SCF) E3 ubiquitin ligase (Tyers and Jorgensen, 2000; Willems et al., 2004). For nearly 13years, a distinct meiotic phenotype was described only in a null mutant of Skp1 in Arabidopsis thaliana, namely arabidopsis-skp1-like1-1 (ask1-1) (Yang ...

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in meiosis.

The first similarity is that the numbers of spores produced by a meiocyte range from two to more than four spores in ask1-1 (Yang et al., 1999) and the yeast skp1 mutants. In many meiotic mutants, the meiotic products produced by a meiocyte are either more or fewer than the normal four spores. The wide range of meiotic product number per meiocyte places ask1-1 and the yeast skp1 mutants in a rare group. The second similarity is indicated by the morphology and behavior of chromosomes during meiosis I. Chromosomes entangle, non-disjoin, are stretched by the anaphase spindle, and as a result, are unevenly distributed to meiotic products in both ask1-1 (Yang et al., 1999; Wang et al., 2004) and the yeast skp1 mutants. Chromosomes are asynaptic in prophase I in ask1-1 (Wang et al., 2004). Fission yeast normally undergoes homologous chromosome pairing instead of synapsis in prophase I. It is unknown whether the homologous chromosome pairing in the yeast skp1 mutants is ...

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The Conserved Function Of Skp1. (2012, December 1). Retrieved January 22, 2025, from http://www.essayworld.com/essays/The-Conserved-Function-Of-Skp1/102057

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PAPER DETAILS

Added: 12/1/2012 09:01:23 AM
Submitted By: forgedstrength
Category: Biology
Type: Premium Paper
Words: 1097
Pages: 4

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