Current Status Of Malaria Vaccinology

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head directly for the
hepatic cells of the liver where they multiply by asexual fission to
produce merozoites. These merozoites can now travel one of two paths. They
can go to infect more hepatic liver cells or they can attach to and
penetrate erytherocytes. When inside the erythrocytes the plasmodium
enlarges into uninucleated cells called trophozites The nucleus of this
newly formed cell then divides asexually to produce a schizont, which has
6-24 nuclei. Now the multinucleated schizont then divides to produce
mononucleated merozoites . Eventually the erythrocytes reaches lysis and
as result the merozoites enter the bloodstream and infect more
erythrocytes. This cycle repeats itself every 48-72 hours (depending on
the species of plasmodium involved in the original infection) The sudden
release of merozoites toxins and erythrocytes debris is what causes the
fever and chills associated with Malaria.

Of course the disease must be able to transmit itself for survival. This
is done ...

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they could compare a possible Malaria vaccine Their article said
that "simple epidemiological theory states that the critical fraction (p)
of all people to be immunised with a combined vaccine (MMR) to ensure
eradication of all three pathogens is determined by the infection that
spreads most quickly through the population; that is by the age of one
with the largest basic case reproduction number Ro. If a vaccine can be
made against the strain with the highest Ro it could provide immunity to
all malaria plasmodium "

Another problem faced by immunologists is the difficulty in identifying
the exact antigens which are targeted by a protective immune response.
Isolating the specific ...

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