Current Status Of Malaria Vaccinology

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head directly for the hepatic cells of the liver where
they multiply by asexual fission to produce merozoites. These merozoites can now
travel one of two paths. They can go to infect more hepatic liver cells or they
can attach to and penetrate erytherocytes. When inside the erythrocytes the
plasmodium enlarges into uninucleated cells called trophozites The nucleus of
this newly formed cell then divides asexually to produce a schizont, which has
6-24 nuclei.

Now the multinucleated schizont then divides to produce mononucleated merozoites
. Eventually the erythrocytes reaches lysis and as result the merozoites enter
the bloodstream and infect more erythrocytes. This cycle repeats itself every
48-72 hours (depending on the species of plasmodium involved in the original
infection) The sudden release of merozoites toxins and erythrocytes debris is
what causes the fever and chills associated with Malaria.

Of course the disease must be able to transmit itself for survival. This is ...

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which they could compare a possible Malaria
vaccine Their article said that "simple epidemiological theory states that the
critical fraction (p) of all people to be immunised with a combined vaccine
(MMR) to ensure eradication of all three pathogens is determined by the
infection that spreads most quickly through the population; that is by the age
of one with the largest basic case reproduction number Ro. In case the of MMR
this is measles with Ro of around 15 which implies that p> 1-1/Ro » 0.93
Gupta et al points out that if a population of malaria parasite consists of a
collection of pathogens or strains that have the same properties as common
childhoodviruses, the vaccine ...

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