Hemophilia

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of the
cases, this coagulant protein is reduced but in a rare amount of
cases, this protein is present by immunoassay but defective.4
Haemophilia A is the most common severe bleeding disorder and
approximately 1 in 10,000 males is effected. The most common types
of bleeding are into the joints and muscles. Haemophilia is severe
if the factor VIII:C levels are less that 1 %, they are moderate if
the levels are 1-5% and they are mild if they levels become 5+%.5
(2)
Those with mild haemophilia bleed only in response to major trauma
or surgery. As for the patients with severe haemophilia, they can
bleed in response to relatively mild trauma and will bleed
spontaneously.
In haemophiliacs, the levels of the factor VIII:C are reduced.
If the plasma from a haemophiliac person mixes with that of a
normal person, the Partial thromboplastin time (PTT) should become
normal. Failure of the PTT to become normal is automatically
diagnostic of the presence of a factor VIII inhibitor. The ...

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