Breast Cancer 2

Scientists have finally found out why MPA medroxyprogesterone, otherwise known as Provera performs just as well in low doses in small children who are dealing with early sex traits, as it does for women in high doses with breast cancer. You may have heard of Provera before as the drug that delivers hormone replacement therapy for women who are going through menopause.
Two scientists, named Lee and Auchus were trying to figure out why Provera is able to treat both early puberty as well as breast cancer. During the pre-teen years a chemical is released in the brain called gonadotropin-releasing hormone (GnRH). In a normal pre-teen body GnRH tells the ovaries and testes when to start ...

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steroid hormones it must convert cholesterol into estrogens and other related substances. In order for this process to take place, several steps are involved which are controlled by a certain enzyme. In knowing this, Lee wanted to find out if blocking the action of an enzyme would be reached with high doses of Provera.
What Lee and Auchus found out was that Provera could inhibit certain enzymes, (3HSDII) which influence hormone production, that low doses of Provera could disrupt GnRH production and high doses were needed for a therapeutic effect. By knowing all this, it brings about new ideas for drug therapy when dealing with certain diseases. Not only that, but 3HSDII enzyme may be great to treat breast cancer. In this study Lee and Auchus used yeast cells instead of human cells. This allows them to study a single enzyme along with the effects that drugs may have on the production of steroids. Another advantage in using yeast cells is that these cells allow the ...

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PAPER DETAILS

Added: 4/3/2006 12:42:00 AM
Category: Science & Nature
Type: Premium Paper
Words: 532
Pages: 2

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