Ovarian Cancer

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amplification or mutation, aberrant tumor
suppressor expression or mutation. Also, subversion of host antitumor immune
responses may play a role in the pathogenesis of cancer (Sharp, 77).

Ovarian clear cell adenocarcinoma was first described by Peham in 1899
as "hypernephroma of the ovary" because of its resemblance to renal cell
carcinoma. By 1939, Schiller noted a histologic similarity to mesonephric
tubules and classified these tumors as "mesonephromas." In 1944, Saphir and
Lackner described two cases of "hypernephroid carcinoma of the ovary" and
proposed "clear cell" adenocarcinoma as an alternative term. Clear cell tumors
of the ovary are now generally considered to be of mullerian and in the genital
tract of mullerian origin. A number of examples of clear cell adenocarcinoma
have been reported to arise from the epithelium of an endometriotic cyst
(Yoonessi, 289). Occasionally, a renal cell carcinoma metastasizes to the
ovary and may be confused with a ...

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than patients with
nonmetastatic disease. Patients with OCCA are also more likely to have Stage I
disease than are patients with ovarian epithelial cancer in general (Kennedy,
348).

Histologic grade has been useful as an initial prognostic determinant in
some studies of epithelial cancers of the ovary. The grading of ovarian clear
cell adenocarcinoma has been problematic and is complicated by the multiplicity
of histologic patterns found in the same tumor. Similar problems have been
found in attempted grading of clear cell adenocarcinoma of the endometrium
(Disaia, 176). Despite these problems, tumor grading has been attempted but has
failed to demonstrate prognostic ...

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