Sickle Cell Anemia

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discovered that an abnormal form of hemoglobin was the reason for the sickness in sickle cell patients. These two took a train together and started talking about . Castle told Pauling about how the cells in sickle cell patients sickled when their oxygen level is low. Paling was amazed by this conversation and did further research on the disease. After that
Pauling was able to tell which patient had sickle cell trait and which one had the disease.
In 1956, Dr. Vernon Ingram made a distinction between normal and abnormal hemoglobin. Dr. Ingram used Pauling’s test to find the key difference. Like other proteins, hemoglobin is made up of chains of smaller chemical building blocks and amino acids. Dr. Ingram used enzymes of other chemicals to break the bond in the hemoglobin molecule. He discovered two proteins had different amino acids in one spot on the chain. Linus Pauling was a pioneer in sickle cell disease research.
In December 1968, Jessie Jackson led a protest ...

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for sickle cell treatment.
A British research team reported the successful transfer to adult mice of the human gene that directs bet hemoglobin production. A Cancer drug, hydroxyura, was found to stimulate fetal hemoglobin production preventing effects of sickle cell disease in 1990. During 1993, a National Institutes of Health panel recommended universal newborn screening for sickle cell disease.
Mia Xyloportas, the AHEPA Cooley’s Anemia poster child, was born with beta- thalassemia. She received blood transfusion about once a month; when she was four year old chelation therapy was added. Mia was a happy active child and paid no attention to the treatments. When she was ...

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