Haemophilia

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In most of the cases, this coagulant
protein is reduced but in a rare amount of cases, this protein is present
by immunoassay but defective.4 Haemophilia A is the most common severe
bleeding disorder and approximately 1 in 10,000 males is effected. The most
common types of bleeding are into the joints and muscles. Haemophilia is
severe if the factor VIII:C levels are less that 1 %, they are moderate if
the levels are 1-5% and they are mild if they levels become 5+%.5

Those with mild haemophilia bleed only in response to major trauma or
surgery. As for the patients with severe haemophilia, they can bleed in
response to relatively mild trauma and will bleed spontaneously.

In haemophiliacs, the levels of the factor VIII:C are reduced. If the
plasma from a haemophiliac person mixes with that of a normal person, the
Partial thromboplastin time (PTT) should become normal. Failure of the PTT
to become normal is automatically diagnostic of the presence of a factor
VIII ...

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