Haemophilia

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In most of the cases, this coagulant protein is reduced
but in a rare amount of cases, this protein is present by immunoassay but
defective. Haemophilia A is the most common severe bleeding disorder and
approximately 1 in 10,000 males is effected. The most common types of bleeding
are into the joints and muscles. Haemophilia is severe if the factor VIII:C
levels are less that 1 %, they are moderate if the levels are 1-5% and they are
mild if they levels become 5+%.

Those with mild haemophilia bleed only in response to major trauma or
surgery. As for the patients with severe haemophilia, they can bleed in
response to relatively mild trauma and will bleed spontaneously.

In haemophiliacs, the levels of the factor VIII:C are reduced. If the
plasma from a haemophiliac person mixes with that of a normal person, the
Partial thromboplastin time (PTT) should become normal. Failure of the PTT to
become normal is automatically diagnostic of the presence of a factor ...

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