Inhibitory Potential Changes of Fluoxetine (Prozac)

Over the past several decades many scientists have explored the various possible links between the function of neurotransmitters in the brain and mood disorders. The neurotransmitter serotonin, found widely in plants, animals and humans has been a particular focus. Scientists who specialize in examining the function and effect of serotonin on the mind and body argue that imbalances in the levels and function of serotonin can be linked to disturbances in mood, anxiety, satiety, cognition, aggression and sexual drives (Tollefson and Rosenbalum, 2001). More specifically, these scientists suggest that this "decreased serotonergic neurotransmission plays an important role in the ...

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into the synapse from the cytoplasmic and vesicular reservoirs. Following release, serotonin is principally inactivated by reuptake into nerve terminals through a sodium/potassium (Na+/K+) adenosine triphosphatase (ATPase) dependent carrier." (Tollefson and Rosenbalum, p. 27, 2001). Problems arise when too much serotonin is recaptured in the reuptake process during synapse or when to little serotonin is being locally manufactured in the central nervous system. As a result, too few serotonin neurotransmitters are able to make it across the synaptic cleft to stimulate postsynaptic receptors. Moreover, "in the absence of pharmacological manipulation, the reuptake of serotonin into the presynaptic nerve terminal typically leads to its inactivation" (Tollefson and Rosenbalum, p. 32, 2001).

Low levels of serotonin have been most commonly linked to depression. For this reason, there have been many attempts by neuroscientists to develop antidepressant drugs that can ...

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PAPER DETAILS
Added: 4/13/2011 03:40:07 PM
Submitted By: therunner456
Category: Health & Medicine
Type: Premium Paper
Words: 774
Pages: 3

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