Lyme Disease
The National Organization for Rare Disorders (NORD), P.O. Box 8923, New
Fairfield, CT 06812, (203) 746-6518
Lyme Arthritis
General Discussion --------------------------------
** REMINDER **
The information contained in the Rare Disease Database is provided for
educational purposes only. It should not be used for diagnostic or
treatment purposes. If you wish to obtain more information about this
disorder, please contact your personal physician and/or the agencies listed
in the "Resources" section of this report.
Lyme disease is a tick-transmitted inflammatory disorder characterized
by an early focal skin lesion, and subsequently a growing red area on the
skin (erythema ...
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clearing, to a
diameter as large as 50 cm (c. 12 in.). Approximately 25% of patients with
Lyme disease report having been bitten at that site by a tiny tick 3 to 32
days before onset of ECM. The lesion may be warm to touch. Soon after
onset nearly half the patients develop multiple smaller lesions without
hardened centers. ECM generally lasts for a few weeks. Other types of
lesions may subsequently appear during resolution. Former skin lesions may
reappear faintly, sometimes before recurrent attacks of arthritis. Lesions
of the mucous membranes do not occur in Lyme disease.
The most common symptoms accompanying ECM, or preceding it by a few
days, may include malaise, fatigue, chills, fever, headache and stiff neck.
Less commonly, backache, muscle aches (myalgias), nausea, vomiting, sore
throat, swollen lymph glands, and an enlarged spleen may also be present.
Most symptoms are characteristically intermittent and changing, but
malaise and fatigue may linger ...
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motor and sensory radiculo-neuritis (symmetric weakness, pain,
strange sensations in the extremities, usually occurring first
in
the legs)
6. injury to single nerves causing diminished nerve response
(mononeuritis multiplex)
7. inflammation of the spinal cord (myelitis).
Abnormalities in the heart muscle (myocardium) occur in approximately
8% of patients with Lyme disease within weeks of ECM. They may include
fluctuating degrees of atrioventricular block and, less commonly,
inflammation of the heart sack and heart muscle (myopericarditis) with
reduced blood volume ejected from the left ventricle and an enlarged heart
(cardiomegaly).
When Lyme ...
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